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Stapled Peptide Inhibitors of Autophagy Adapter LC3B
Author(s) -
Cerulli Robert A.,
Shehaj Livia,
Brown Hawley,
Pace Jennifer,
Mei Yang,
Kritzer Joshua A.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000636
Subject(s) - signal transducing adaptor protein , autophagy , adapter (computing) , peptide , chemistry , microbiology and biotechnology , computational biology , biochemistry , plasma protein binding , biology , signal transduction , computer science , apoptosis , operating system
For natural ligands of the human autophagy adaptor protein LC3B, the key recognition motif binds in an extended conformation (upper left). We report extensive structure–activity relationships for this important protein–protein interaction. We also used this information to design an artificial “staple” (shown in orange) that improves the binding and biological properties of the ligand peptides. More information can be found in the full paper by J. A. Kritzer et al.