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Front Cover: Effect of Regiochemistry and Methylation on the Anticancer Activity of a Ferrocene‐Containing Organometallic Nucleoside Analogue (ChemBioChem 17/2020)
Author(s) -
Ismail Media K.,
Khan Zahra,
Rana Marium,
Horswell Sarah L.,
Male Louise,
Nguyen Huy V.,
Perotti Alessio,
RomeroCanelón Isolda,
Wilkinson Edward A.,
Hodges Nikolas J.,
Tucker James H. R.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000547
Subject(s) - ferrocene , regioselectivity , chemistry , nucleoside analogue , stereochemistry , methylation , nucleoside , structural isomer , combinatorial chemistry , biochemistry , dna , catalysis , electrode , electrochemistry
Iron works : A ferrocene derivative, one of a series of ferronucleosides designed by the Tucker group, shows micromolar toxicity in a range of cancer cell lines. Their latest research shows the importance to activity of having arms in adjacent positions, with the 1,1’‐regioisomer much less active in bone cancer cell lines. On the other hand, N‐ or O‐methylation has much less of an effect; this rules out a conventional mechanism of action for a nucleoside, giving further weight to one that involves the iron centre. More information can be found in the full paper by N. J. Hodges, J. H. R. Tucker et al.