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Noncanonical Amino Acids in Synthetic Biosafety and Post‐translational Modification Studies
Author(s) -
Gang Donghyeok,
Park Heesung
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000437
Subject(s) - biosafety , posttranslational modification , amino acid , computational biology , synthetic biology , recombinant dna , chemistry , in vivo , combinatorial chemistry , biochemistry , biology , nanotechnology , microbiology and biotechnology , enzyme , materials science , gene
Abstract The incorporation of noncanonical amino acids (ncAAs) has been extensively studied because of its broad applicability. In the past decades, various in vitro and in vivo ncAA incorporation approaches have been developed to generate synthetic recombinant proteins. Herein, we discuss the methodologies for ncAA incorporation, and their use in diverse research areas, such as in synthetic biosafety and for studies of post‐translational modifications.