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Learning about Enzyme Stability against Organic Cosolvents from Structural Insights by Ion Mobility Mass Spectrometry
Author(s) -
Sproß Jens,
Yamashita Yasunobu,
Gröger Harald
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000412
Subject(s) - ion mobility spectrometry , chemistry , mass spectrometry , enzyme , protein data bank (rcsb pdb) , ion , solvent , enzyme catalysis , chromatography , stereochemistry , organic chemistry
In enzyme catalysis , there often comes the time when you ask yourself if the amount of organic solvent is affecting your enzyme. When this happened to us, we were able to use ion mobility spectrometry and mass spectrometry (IMS‐MS) to get a closer insight when our enzyme starts to unfold and loose activity. More information can be found in the communication by J. Sproß, Y. Yamashita and H. Gröger. (The protein structure is a part of the structure PDB ID: 6MYW.)