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PR10/Bet v1‐like Proteins as Novel Contributors to Plant Biochemical Diversity
Author(s) -
Morris Jeremy S.,
Caldo Kristian Mark P.,
Liang Siyu,
Facchini Peter J.
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000354
Subject(s) - biochemistry , computational biology , chemistry , biology
Pathogenesis‐related (PR) proteins constitute a broad class of plant proteins with analogues found throughout nature from bacteria to higher eukaryotes. PR proteins were first noted in plants as part of the hypersensitive response, but have since been assigned an array of biological roles. The PR10/Bet v1‐like proteins are a subset of PR proteins characterized by an ability to bind a wide range of lipophilic ligands, uniquely positioning them as contributors to specialized biosynthetic pathways. PR10/Bet v1‐like proteins participate in the production of plant alkaloids and phenolics including flavonoids, both as general binding proteins and in special cases as catalysts. Owing initially to the perceived allergenic properties of PR10/Bet v1‐like proteins, many were studied at the structural level to elucidate the basis for ligand binding. These studies provided a foundation for more recent efforts to understand higher‐level structural order and how PR10/Bet v1‐like proteins catalyse key reactions in plant pathways. Synthetic biology aimed at reconstituting plant‐specialized metabolism in microorganisms uses knowledge of these proteins to fine‐tune performance in new systems.