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Convergent Evolution of Fungal Cysteine Dioxygenases
Author(s) -
Flückger Sebastian,
Igareta Nico V.,
Seebeck Florian P.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000317
Subject(s) - ergothioneine , cysteine , biochemistry , enzyme , biosynthesis , convergent evolution , chemistry , bacteria , heme , biology , gene , genetics , phylogenetics , antioxidant
Cupin‐type cysteine dioxygenases (CDOs) are non‐heme iron enzymes that occur in animals, plants, bacteria and in filamentous fungi. In this report, we show that agaricomycetes contain an entirely unrelated type of CDO that emerged by convergent evolution from enzymes involved in the biosynthesis of ergothioneine. The activity of this CDO type is dependent on the ergothioneine precursor N ‐α‐trimethylhistidine. The metabolic link between ergothioneine production and cysteine oxidation suggests that the two processes might be part of the same chemical response in fungi, for example against oxidative stress.