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Multivalent Antibody‐Recruiting Macromolecules: Linking Increased Binding Affinity with Enhanced Innate Immune Killing
Author(s) -
Uvyn Annemiek,
De Geest Bruno G.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000261
Subject(s) - antibody dependent cell mediated cytotoxicity , antibody , cytotoxicity , innate immune system , immune system , phagocytosis , antigen antibody complex , chemistry , biology , microbiology and biotechnology , immunology , monoclonal antibody , biochemistry , in vitro
Antibody‐recruiting molecules (ARMs) are a novel class of immunotherapeutics. They are capable of introducing antibodies onto disease‐relevant targets such as cancer cells, bacterial cells or viruses. This can induce antibody‐mediated immune responses such as antibody‐dependent cellular cytotoxicity (ADCC), complement‐dependent cytotoxicity (CDC) and antibody‐dependent phagocytosis (ADCP), which can kill the pathogen. In contrast to the classic ARMs, multivalent ARMs could offer the advantage of increasing the efficiency of antibody recruitment and subsequent innate immune killing. Such compounds consist of multiple target‐binding termini (TBT) and/or antibody‐binding termini (ABT). Those multivalent interactions are able to convert low binding affinities into increased binding avidities. This minireview summarizes the current status of multivalent ARMs and gives insight into possible benefits, hurdles still to be overcome and future perspectives.