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Cover Feature: An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases (ChemBioChem 10/2020)
Author(s) -
VichierGuerre Sophie,
Ku Therese C.,
Pochet Sylvie,
SeleyRadtke Katherine L.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000241
Subject(s) - purine nucleoside phosphorylase , chemistry , glycosylation , nucleoside , stereochemistry , combinatorial chemistry , purine , enzyme , biochemistry
A new and facile route to synthesize novel distal and proximal fleximer nucleosides, as well as tricyclic expanded purine nucleosides has been developed. A tricyclic thieno‐expanded base, as well as several distal and proximal flex‐bases were converted in excellent yields to their corresponding nucleosides by enzymatic transglycosylations catalyzed by N ‐deoxyribosyltransferase from L. leichmannii (LlNDT) or E. coli purine nucleoside phosphorylase (PNP). Glass model created by Tony Baney (UMBC). More information can be found in the communication by K. L. Seley‐Radtke et al. on page 1412 in Issue 10, 2020 (DOI: 10.1002/cbic.201900714).