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Front Cover: Hijacking Translation Initiation for Synthetic Biology (ChemBioChem 10/2020)
Author(s) -
Tharp Jeffery M.,
Krahn Natalie,
Varshney Umesh,
Söll Dieter
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000239
Subject(s) - front cover , cover (algebra) , amino acid , translation (biology) , position (finance) , bioorthogonal chemistry , synthetic biology , computer science , front (military) , computational biology , chemistry , biology , biochemistry , combinatorial chemistry , physics , click chemistry , engineering , business , messenger rna , mechanical engineering , finance , gene , meteorology
The front cover picture shows not only the hurdles to overcome but also the opportunities that arise from initiating with noncanonical amino acids. The initiating position opens possibilities for amino acids modified at the α‐amine to be incorporated into a protein, an achievement only possible at the first amino acid position. Designing a successful strategy through in vitro and in vivo methods poses unique challenges that have to be surmounted for successful translation. More information can be found in the minireview by D. Söll et al. on page 1387 in Issue 10, 2020 (DOI: 10.1002/cbic.202000017).