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Cover Feature: Coculturing of Mosquito‐Microbiome Bacteria Promotes Heme Degradation in Elizabethkingia anophelis (ChemBioChem 9/2020)
Author(s) -
Ganley Jack G.,
D'Ambrosio Hannah K.,
Shieh Meg,
Derbyshire Emily R.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000216
Subject(s) - heme , biliverdin , microbiome , biology , pathogen , microbiology and biotechnology , bacteria , computational biology , chemistry , biochemistry , heme oxygenase , genetics , enzyme
Bacterial communities that reside in mosquitoes can influence host biology and pathogen transmission. Through coculturing of mosquito‐microbiome members, Elizabethkingia anophelis was identified as a dominant species. When grown with another microbiome member Pseudomonas sp., E. anophelis upregulates the heme‐binding protein HemS. We show that HemS degrades heme to biliverdin IX β and biliverdin IX δ . More information can be found in the communication by E. R. Derbyshire et al. on page 1279 in Issue 9, 2020 (DOI: 10.1002/cbic.201900675).