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Biocatalytic Alkylation Cascades: Recent Advances and Future Opportunities for Late‐Stage Functionalization
Author(s) -
McKean Iain J. W.,
Hoskisson Paul A.,
Burley Glenn A.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000187
Subject(s) - alkylation , cofactor , methyltransferase , chemistry , alkyl , combinatorial chemistry , biocatalysis , nanotechnology , enzyme , catalysis , organic chemistry , biochemistry , methylation , materials science , reaction mechanism , gene
This Concept article describes the latest developments in the emerging area of late‐stage biocatalytic alkylation. Central to these developments is the ability to efficiently prepare S ‐adenosyl methionine (SAM) cofactor analogues and couple this with enzymatic alkyl transfer. Recent developments in the enzymatic synthesis of SAM cofactor analogues are summarized first, followed by their application as alkyl transfer agents catalyzed by methyltransferases (MTases). Second, innovative methods to regenerate SAM cofactors by enzymatic cascades is reported. Finally, future opportunities towards establishing a generalized platform for late‐stage alkylation are described.