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Front Cover: 5‐Benzylidene‐4‐Oxazolidinones Are Synergistic with Antibiotics for the Treatment of Staphylococcus aureus Biofilms (ChemBioChem 7/2020)
Author(s) -
Frohock Bram H.,
Gilbertie Jessica M.,
Daiker Jennifer C.,
Schnabel Lauren V.,
Pierce Joshua G.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000168
Subject(s) - biofilm , staphylococcus aureus , microbiology and biotechnology , antibiotics , antibiotic resistance , chemistry , front cover , biology , bacteria , cover (algebra) , genetics , mechanical engineering , engineering
By using an expanded set of 5‐benzylidene‐4‐oxazolidinones it was possible to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms and—in combination with common antibiotics—to significantly reduce the bacterial load in a robust collagen–matrix biofilm model. In addition to traditional resistance mechanisms, most chronic and recurring infections are further made tolerant to antibiotic action by the presence of biofilms and novel strategies to combat these bacterial communities are urgently needed. More information can be found in the communication by J. G. Pierce et al. on page 933 in Issue 7, 2020 (DOI: 10.1002/cbic.201900633).