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Cover Feature: Molecular Structure of Binary Chromium(III)–DNA Adducts (ChemBioChem 5/2020)
Author(s) -
Brown Silas,
Lockart Molly M.,
Thomas C. Sumner,
Bowman Michael K.,
Woski Stephen A.,
Vincent John B.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000078
Subject(s) - chromium , chromate conversion coating , chemistry , carcinogen , dna , adduct , carcinogenesis , biochemistry , combinatorial chemistry , gene , organic chemistry
Chromate compounds are carcinogenic when inhaled , but the mechanism of tumorigenesis is unknown. One hypothesis involves transport of chromium into cells where reduction to chromium(III) and binding of the chromium(III) to DNA occurs. The elucidation of the molecular‐level structures of the resulting metal–DNA adducts forms a crucial bridge between exposure to the carcinogen and the development of mutations and cancer in humans. More information can be found in the communication by J. B. Vincent et al. on page 628 in Issue 5, 2020 (DOI: 10.1002/cbic.201900436).