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Bimetallic CuCo 2 S 4 Nanozymes with Enhanced Peroxidase Activity at Neutral pH for Combating Burn Infections
Author(s) -
Li Dandan,
Guo Qianqian,
Ding Liming,
Zhang Wei,
Cheng Lu,
Wang Yanqiu,
Xu Zhuobin,
Wang Huihui,
Gao Lizeng
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000066
Subject(s) - bimetallic strip , peroxidase , antibacterial activity , chemistry , staphylococcus aureus , bacteria , combinatorial chemistry , nuclear chemistry , nanotechnology , enzyme , catalysis , materials science , organic chemistry , biology , genetics
Peroxidase‐mimicking nanozymes that can generate toxic hydroxyl radicals ( . OH) hold great promise as antibacterial alternatives. However, most of them display optimal performance under strongly acidic conditions (pH 3–4), and are thus not feasible for many medical uses, including burn infections with a wound pH close to neutral. Herein, we report a copper‐based nanozyme (CuCo 2 S 4 ) that exhibits intrinsic peroxidase‐like activity and can convert H 2 O 2 into . OH at neutral pH. In particular, bimetallic CuCo 2 S 4 nanoparticles (NPs) exhibited enhanced peroxidase‐like activity and antibacterial capacity, superior to that of the corresponding monometallic CuS and CoS NPs. The CuCo 2 S 4 nanozymes possessed excellent ability to kill various bacteria, including methicillin‐resistant Staphylococcus aureus (MRSA). Furthermore, this CuCo 2 S 4 nanozymes could effectively disrupt MRSA biofilms in vitro and accelerate MRSA‐infected burn healing in vivo. This work provides a new peroxidase mimic to combat bacteria in neutral pH milieu and this CuCo 2 S 4 nanozyme could be a promising antibacterial agent for the treatment of burn infections.