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Cover Feature: Genetic Encoding of a Bioconjugation Handle for [2+2+2] Cycloaddition Reactions (ChemBioChem 3/2020)
Author(s) -
Travis Christopher R.,
King Elizabeth A.,
Gaunt Gillian H.,
Young Douglas D.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000012
Subject(s) - bioconjugation , bioorthogonal chemistry , conjugate , cover (algebra) , cycloaddition , combinatorial chemistry , chemistry , encoding (memory) , feature (linguistics) , computational biology , computer science , click chemistry , nanotechnology , biology , biochemistry , materials science , artificial intelligence , catalysis , mathematical analysis , mechanical engineering , linguistics , philosophy , mathematics , engineering
The development of novel bioconjugation strategies is useful for various therapeutic and diagnostic applications. This work describes the synthesis and genetic encoding of an unnatural amino acid that serves as a functional handle for numerous bioconjugations. In particular it can be employed in bioorthogonal [2+2+2] cycloaddition reactions to either conjugate a small‐molecule probe/drug or to immobilize a protein on a surface. More information can be found in the communication by D. D. Young et al. on page 310 in Issue 3, 2020 (DOI: 10.1002/cbic.201900391).