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Front Cover: Lamprey Parapinopsin (“UVLamP”): a Bistable UV‐Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways (ChemBioChem 5/2020)
Author(s) -
Eickelbeck Dennis,
Rudack Till,
Tennigkeit Stefan Alexander,
Surdin Tatjana,
Karapinar Raziye,
Schwitalla JanClaudius,
Mücher Brix,
Shulman Maiia,
Scherlo Marvin,
Althoff Philipp,
Mark Melanie D.,
Gerwert Klaus,
Herlitze Stefan
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900720
Subject(s) - optogenetics , bistability , opsin , lamprey , millisecond , g protein coupled receptor , rhodopsin , chemistry , biophysics , neuroscience , biology , physics , signal transduction , microbiology and biotechnology , optoelectronics , biochemistry , fishery , retinal , astronomy
Optogenetic control of G protein‐coupled receptor pathways : The Japanese lamprey ( Lethenteron camtschaticum ) parapinopsin (“UVLamP”) serves as a minimally invasive, narrow‐bandwidth, bistable, next‐generation optogenetic probe for controlling the G i/o pathway. A millisecond UV light pulse allows for sustained pathway activation that can be switched off with a millisecond blue light pulse on demand. The first structural model of parapinopsin in the dark state reveals novel interaction partners shedding light on the mechanisms responsible for opsin bistability. More information can be found in the communication by D. Eickelbeck, K. Gerwert, S. Herlitze et al. on page 612 in Issue 5, 2020 (DOI: 10.1002/cbic.201900485).