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Cover Feature: Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 (ChemBioChem 24/2019)
Author(s) -
Cromm Philipp M.,
Adihou Hélène,
Kapoor Shobhna,
VazquezChantada Mercedes,
Davey Paul,
Longmire David,
Hennes Elisabeth,
Hofer Walter,
Küchler Philipp,
Chiarparin Elisabetta,
Waldmann Herbert,
Grossmann Tom N.
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900704
Subject(s) - cytokinesis , chemistry , peptide , protein data bank (rcsb pdb) , microbiology and biotechnology , biochemistry , biology , cell , cell division
UNC119 proteins mediate the activation and transport of N‐myristoylated proteins. In particular, UNC119a (grey mesh, PDB ID: 3RBQ) plays a crucial role in cytokinesis. In their communication, H. Waldmann, Tom N. Grossmann, et al. on page 2987 in Issue 24, 2019 (DOI: 10.1002/cbic.201900615), report the use of a lipidated peptide (red) originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated stapled peptides that target UNC119a. Cell‐permeable binders of UNC119a were generated that induce the accumulation of cytokinetic and binucleated cells (as shown), thus suggesting UNC119a as a potential target for the inhibition of cytokinesis.