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Front Cover: Modulation and Visualization of EF‐G Power Stroke During Ribosomal Translocation (ChemBioChem 23/2019)
Author(s) -
Yin Heng,
Gavriliuc Miriam,
Lin Ran,
Xu Shoujun,
Wang Yuhong
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900662
Subject(s) - ribosome , ribosomal rna , chromosomal translocation , chemistry , protein subunit , biophysics , ribosomal protein , biology , biochemistry , rna , gene
Power to the finish line : During ribosomal translocation, elongation factor G (EF‐G) produces a significant power stroke that is the main driving force for the ribosome to move forward one codon at a time (top kangaroo). The force is generated through a large change in conformation (green, ribosome large subunit; red, EF‐G). Consequently, when a crosslinker is implemented, only a weak power stroke is generated (bottom kangaroo). Interestingly, the ribosome still moves by one codon at a time, but at a slower rate. More information can be found in the full paper by S. Xu, Y. Wang, et al. on page 2927 in Issue 23, 2019 (DOI: 10.1002/cbic.201900276).