Front Cover: Modulation and Visualization of EF‐G Power Stroke During Ribosomal Translocation (ChemBioChem 23/2019) | Zendy

Yin Heng | Zendy; Gavriliuc Miriam | Zendy; Lin Ran | Zendy; Xu Shoujun | Zendy; Wang Yuhong | Zendy

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Front Cover: Modulation and Visualization of EF‐G Power Stroke During Ribosomal Translocation (ChemBioChem 23/2019)

Author(s) -

Yin Heng,

Gavriliuc Miriam,

Lin Ran,

Xu Shoujun,

Wang Yuhong

Publication year - 2019

Publication title -

chembiochem

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201900662

Subject(s) - ribosome , ribosomal rna , chromosomal translocation , chemistry , protein subunit , biophysics , ribosomal protein , biology , biochemistry , rna , gene

Power to the finish line : During ribosomal translocation, elongation factor G (EF‐G) produces a significant power stroke that is the main driving force for the ribosome to move forward one codon at a time (top kangaroo). The force is generated through a large change in conformation (green, ribosome large subunit; red, EF‐G). Consequently, when a crosslinker is implemented, only a weak power stroke is generated (bottom kangaroo). Interestingly, the ribosome still moves by one codon at a time, but at a slower rate. More information can be found in the full paper by S. Xu, Y. Wang, et al. on page 2927 in Issue 23, 2019 (DOI: 10.1002/cbic.201900276).

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