Cover Feature: Strong Binding and Off–On Signaling Functions of Deep‐Red Fluorescent TO‐PRO‐3 for Influenza A Virus RNA Promoter Region (ChemBioChem 21/2019) | Zendy

Sato Yusuke | Zendy; Aiba Yuri | Zendy; Yajima Sayaka | Zendy; Tanabe Takaaki | Zendy; Higuchi Kei | Zendy; Nishizawa Seiichi | Zendy

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Cover Feature: Strong Binding and Off–On Signaling Functions of Deep‐Red Fluorescent TO‐PRO‐3 for Influenza A Virus RNA Promoter Region (ChemBioChem 21/2019)

Author(s) -

Sato Yusuke,

Aiba Yuri,

Yajima Sayaka,

Tanabe Takaaki,

Higuchi Kei,

Nishizawa Seiichi

Publication year - 2019

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201900621

Subject(s) - rna , fluorescence , influenza a virus , virus , chemistry , cover (algebra) , biology , binding site , computational biology , biophysics , virology , biochemistry , gene , physics , mechanical engineering , quantum mechanics , engineering

The cover feature picture shows the deep‐red emission of TO‐PRO‐3, a thiazole orange analogue with a trimethine bridge, that can strongly and selectively bind to the internal loop structure of the influenza A virus RNA promoter region. TO‐PRO‐3 was shown to be a useful fluorescence indicator for assessing the binding capabilities of various test compounds for this RNA region, with a view to developing anti‐influenza drug candidates. More information can be found in the communication by S. Nishizawa et al. on page 2752 in Issue 21, 2019 (DOI: 10.1002/cbic.201900331).

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