Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO 2 ) Donors | Zendy

Malwal Satish R. | Zendy; Pardeshi Kundansingh A. | Zendy; Chakrapani Harinath | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO 2 ) Donors

Author(s) -

Malwal Satish R.,

Pardeshi Kundansingh A.,

Chakrapani Harinath

Publication year - 2020

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201900614

Subject(s) - sulfite , bisulfite , sulfur dioxide , sodium bisulfite , intracellular , chemistry , nucleophile , cell permeability , sulfur , sodium sulfite , combinatorial chemistry , biochemistry , sodium , organic chemistry , catalysis , gene expression , dna methylation , gene

Although sulfur dioxide (SO 2 ) finds widespread use in the food industry as its hydrated sulfite form, a number of aspects of SO 2 biology remain to be completely understood. Of the tools available for intracellular enhancement of SO 2 levels, most suffer from poor cell permeability and a lack of control over SO 2 release. We report 1,2‐cyclic sulfite diesters as a new class of reliable SO 2 donors that dissociate in buffer through nucleophilic displacement to produce SO 2 with tunable release profiles. We provide data in support of the suitability of these SO 2 donors to enhance intracellular SO 2 levels more efficiently than sodium bisulfite, the most commonly used SO 2 donor for cellular studies.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research