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Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO 2 ) Donors
Author(s) -
Malwal Satish R.,
Pardeshi Kundansingh A.,
Chakrapani Harinath
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900614
Subject(s) - sulfite , bisulfite , sulfur dioxide , sodium bisulfite , intracellular , chemistry , nucleophile , cell permeability , sulfur , sodium sulfite , combinatorial chemistry , biochemistry , sodium , organic chemistry , catalysis , gene expression , dna methylation , gene
Although sulfur dioxide (SO 2 ) finds widespread use in the food industry as its hydrated sulfite form, a number of aspects of SO 2 biology remain to be completely understood. Of the tools available for intracellular enhancement of SO 2 levels, most suffer from poor cell permeability and a lack of control over SO 2 release. We report 1,2‐cyclic sulfite diesters as a new class of reliable SO 2 donors that dissociate in buffer through nucleophilic displacement to produce SO 2 with tunable release profiles. We provide data in support of the suitability of these SO 2 donors to enhance intracellular SO 2 levels more efficiently than sodium bisulfite, the most commonly used SO 2 donor for cellular studies.