Premium
Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization
Author(s) -
Hu HongGuo,
Chen PuGuang,
Wang Guanyu,
Wu JunJun,
Zhang BoDou,
Li WenHao,
Davis Rebecca L.,
Li YanMei
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900591
Subject(s) - chemistry , immune system , microbiology and biotechnology , toll like receptor , stimulation , receptor , biophysics , innate immune system , biochemistry , immunology , biology , neuroscience
The activation of toll‐like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be usable as a switch for immune response. Here we have rationally designed and synthesized a photoswitchable Pam 3 CSK 4 derivative— P10 —to control the activation of TLR1/2. The ground‐state trans ‐ P10 was able to stimulate and activate antigen‐presenting cells (APCs) by promoting TLR1/2 heterodimerization. However, cis ‐ P10 , derived from UV irradiation of trans ‐ P10 , reduced the activities of APCs by impeding the TLR1/2 heterodimerization. In the absence of UV radiation, the cis ‐ P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulation. Our results indicated that optical control of TLR1/2 heterodimerization mediated by the photoswitchable P10 offers the potential to regulate immune activation and inflammation.