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Chemical Reporters for Exploring Microbiology and Microbiota Mechanisms
Author(s) -
Zhang Zhenrun J.,
Wang YenChih,
Yang Xinglin,
Hang Howard C.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900535
Subject(s) - chemical biology , microbiology and biotechnology , computational biology , chemistry , biology , nanotechnology , biochemistry , materials science
The advances made in bioorthogonal chemistry and the development of chemical reporters have afforded new strategies to explore the targets and functions of specific metabolites in biology. These metabolite chemical reporters have been applied to diverse classes of bacteria including Gram‐negative, Gram‐positive, mycobacteria, and more complex microbiota communities. Herein we summarize the development and application of metabolite chemical reporters to study fundamental pathways in bacteria as well as microbiota mechanisms in health and disease.