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Front Cover: Generating Cyan Fluorescence with De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence (ChemBioChem 18/2019)
Author(s) -
Guo Jun,
Ramachandran Srinivasan,
Zhong Ruibo,
Lal Ratnesh,
Zhang Feng
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900531
Subject(s) - cyan , tripeptide , fluorescence , amino acid , chemistry , tyrosine , stereochemistry , biochemistry , physics , quantum mechanics , art , visual arts
By using the building blocks of life , amino acids, a broad palette of proteins and peptides has been successfully engineered as useful bio‐functional agents. Nature produces colorful fur, feathers, hair, and eyes through various biochemical modifications of tyrosine‐based pigmentation. However, it is still challenging to construct oligopeptide‐based fluorescent nanostructures with an arbitrary emission wavelength. Inspired by the chromophore of fluorescent proteins, R. Lal, F. Zhang, et al. on page 2324 in Issue 18, 2019 (DOI: 10.1002/cbic.201900166) relate in their communication how they discovered an innovative approach to red‐shift the fluorescence wavelength from ultraviolet to cyan by using de novo tripeptides containing glycine, tyrosine, and lysine, which can form robust dimer structures under moderate oxidizing conditions.