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Cover Feature: Biocompatible Inhibitor Based on Chitosan and Amphiphilic Peptide against Mutant Huntingtin Toxicity (ChemBioChem 16/2019)
Author(s) -
Wahyuningtyas Devi,
Chen WenHao,
Huang ChenHan,
He YuJung,
Huang Joseph JenTse
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900459
Subject(s) - huntingtin , amphiphile , mutant , chitosan , peptide , chemistry , huntingtin protein , toxicity , biocompatible material , biochemistry , biophysics , biology , organic chemistry , copolymer , gene , polymer , medicine , biomedical engineering
An inhibitor based on chitosan and an amphiphilic peptide can interfere with the oligomerization and aggregation process of mutant Huntingtin protein in Huntington's disease. In their full paper, J. J.‐T. Huang et al. on page 2133 in Issue 16, 2019 (DOI: 10.1002/cbic.201900242), demonstrate how positively charged chitosan derived from crab shell can form a complex with amphiphilic peptides composed of glutamic acids and glutamines. The complex can disassemble the mutant Huntingtin inclusion body (shown as a jigsaw puzzle in the figure) and reduce its toxicity.