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Front Cover: Exploring the Minimal RNA Substrate of Flexizymes (ChemBioChem 15/2019)
Author(s) -
Fujino Tomoshige,
Kondo Taishi,
Suga Hiroaki,
Murakami Hiroshi
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900437
Subject(s) - acylation , substrate (aquarium) , rna , amino acid , chemistry , front cover , cover (algebra) , stereochemistry , combinatorial chemistry , biochemistry , biology , catalysis , mechanical engineering , ecology , gene , engineering
We have explored the minimal RNA substrate of flexizymes and developed a simple method for measuring the acylation efficiencies for various amino acids, including non‐proteinogenic amino acids, by using a four‐base RNA substrate (GCCA). The picture illustrates how the small RNA substrate efficiently classifies the incoming amino acid substrates one by one. Amino acid substrates are classified into one of three boxes depending on their acylation efficiencies. More information can be found in the full paper by H. Murakami et al. on page 1959 in Issue 15, 2019 (DOI: 10.1002/cbic.201900150).