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Cover Feature: Synthesis of Erythropoietins Site‐Specifically Conjugated with Complex‐Type N ‐Glycans (ChemBioChem 15/2019)
Author(s) -
Streichert Katharina,
Seitz Carina,
Hoffmann Eugenia,
Boos Irene,
Jelkmann Wolfgang,
Brunner Thomas,
Unverzagt Carlo,
Rubini Marina
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900433
Subject(s) - glycosylation , chemistry , click chemistry , glycan , glycoprotein , alkyne , cover (algebra) , biochemistry , amino acid , conjugated system , computational biology , stereochemistry , combinatorial chemistry , biology , organic chemistry , polymer , catalysis , mechanical engineering , engineering
The significance of N‐glycosylation on the function of glycoproteins is well recognized, but not sufficiently understood. The preparation of homogeneously glycosylated proteins by both chemical synthesis and recombinant expression remains challenging. A semisynthetic approach, based on the site‐specific incorporation of alkyne‐bearing unnatural amino acids combined with click chemistry should open up the possibility to get access to a range of defined glycosylated proteins. More information can be found in the communication by M. Rubini et al. on page 1914 in Issue 15, 2019 (DOI: 10.1002/cbic.201900023).