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Cover Feature: Design of an Ultrafast G Protein Switch Based on a Mouse Melanopsin Variant (ChemBioChem 14/2019)
Author(s) -
Tennigkeit Stefan Alexander,
Karapinar Raziye,
Rudack Till,
Dreier MaxAylmer,
Althoff Philipp,
Eickelbeck Dennis,
Surdin Tatjana,
Grömmke Michelle,
Mark Melanie D.,
Spoida Katharina,
Lübben Mathias,
Höweler Udo,
Herlitze Stefan,
Gerwert Klaus
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900409
Subject(s) - melanopsin , optogenetics , feature (linguistics) , cover (algebra) , neuroscience , gq alpha subunit , chemistry , computational biology , biology , signal transduction , microbiology and biotechnology , retina , g protein , engineering , photopigment , mechanical engineering , linguistics , philosophy
The cover feature picture shows a structural model of the molecular light switch melanopsin symbolically placed in a mouse brain. Light absorption of melanopsin activates signal transduction, controlling cellular functions. In their communication, S. Herlitze, K. Gerwert, et al. on page 1766 in Issue 14, 2019 (DOI: 10.1002/cbic.201900110) present an optogenetically attractive protein‐design strategy that integrates experimental and computational methods. The designed melanopsin variant promises a selective control of distinct G protein signaling pathways within optogenetic applications.