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Boronic Acid Modified Polymer Nanoparticles for Enhanced Bacterial Deactivation
Author(s) -
Gong Haiyue,
Liu Weifeng,
Carlquist Magnus,
Ye Lei
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900406
Subject(s) - boronic acid , polymer , bacteria , chemistry , chloramphenicol , antibiotics , nanoparticle , combinatorial chemistry , nanotechnology , organic chemistry , materials science , biochemistry , biology , genetics
A new method has been developed to enhance the antibacterial efficiency of traditional antibiotics. Chloramphenicol‐imprinted polymer particles were decorated with boronic acid to improve their binding to both Gram‐negative and ‐positive bacteria. The polymer particles have a high antibiotic loading and provide a slow release of the antibiotic payload to deactivate the target bacteria. The boronic acid modified polymer particles not only contribute to enhanced antibacterial efficiency, but also have the potential to act as scavengers to remove unused antibiotic from the environment.