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Cover Feature: Towards Reverse Transcription with an Expanded Genetic Alphabet (ChemBioChem 13/2019)
Author(s) -
Eggert Frank,
Kurscheidt Katharina,
Hoffmann Eva,
KathSchorr Stephanie
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900372
Subject(s) - reverse transcriptase , protein data bank (rcsb pdb) , computational biology , alphabet , transcription (linguistics) , dna , reverse transcription polymerase chain reaction , base pair , biology , genetics , rna , microbiology and biotechnology , chemistry , computer science , messenger rna , gene , biochemistry , philosophy , linguistics
The cover feature picture shows the unnatural hydrophobic base pair TPT3:NaM during reverse transcription, with rTPT3 in the RNA template strand and an incoming dNaM triphosphate. Four retroviral derived reverse transcriptases, as well as a mutant of Taq DNA polymerase with reverse transcriptase activity, are questioned for their ability to handle an expanded genetic alphabet. More information can be found in the communication by S. Kath‐Schorr et al. on page 1642 in Issue 13, 2019 (DOI: 10.1002/cbic.201800808). (Background structure for illustration only: XMRV reverse transcriptase, PDB ID: 4HKQ).