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Conjugated‐Polymer‐Based Nanoparticles with Efficient NIR‐II Fluorescent, Photoacoustic and Photothermal Performance
Author(s) -
Miao Yawei,
Gu Chuantao,
Yu Bing,
Zhu Yaowei,
Zou Wentao,
Shen Youqing,
Cong Hailin
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900309
Subject(s) - photothermal therapy , fluorescence , photoacoustic imaging in biomedicine , conjugated system , nanoparticle , materials science , fluorescence lifetime imaging microscopy , nanotechnology , polymer , optics , physics , composite material
Abstract Fluorescence imaging (FI) and photoacoustic imaging (PA) play important roles in the real‐time assessment of cell‐based therapies. However, the limitations of conventional organic fluorescence contrast agents and the narrow range of the emission wavelength in the first near‐infrared (NIR‐I) window (750–900 nm) hamper applications of fluorescence imaging in living subjects. Herein, we report the design and synthesis of a short‐wave infrared FI contrast agent and PA contrast agent based on a conjugated polymer—poly{2,5‐bis[(5‐thiophen‐2‐yl)methylene]‐3,6‐bis(2‐octyldodecyl)‐2,5‐dihydropyrazine}—and its use to construct multifunctional nanoparticles to simplify photothermal therapy.