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Front Cover: Label‐Free in Situ Monitoring of the DNA Hybridization Chain Reaction by Using Sequence‐Selective Minor‐Groove‐Binding Fluorophores (ChemBioChem 10/2019)
Author(s) -
Sakamoto Takashi,
Yamada Rikuto
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900255
Subject(s) - minor groove , front cover , nucleic acid , dna , in situ , groove (engineering) , fluorescence , metaphor , biology , chemistry , cover (algebra) , biochemistry , optics , engineering , mechanical engineering , organic chemistry , physics , linguistics , philosophy
The front cover picture shows miners working in a Japanese Edo‐period gold mine. To find a “shiny” one, they light‐up the tunnel by using miner‐groove‐binding fluorophores and the products of hybridization chain reaction (HCR). This is a metaphor for research into the development of a label‐free in situ monitoring system for HCR, which might shed light on the “shiny” future of HCR‐based nucleic acids detection technology. The kanji on the tunics of the three miners are kei‐kou “fluorescence” (left), ten‐ryou “under shogunate control” (center), and kaku‐san “nucleic acids” (right). More information can be found in the communication by T. Sakamoto and R. Yamada on page 1242 in Issue 10, 2019 (DOI: 10.1002/cbic.201800738).