Base‐Sequence‐Independent Efficient Redox Switching of Self‐Assembled DNA Nanocages | Zendy

Wang Bang | Zendy; Song Lei | Zendy; Jin Bang | Zendy; Deng Ning | Zendy; Wu Xiaojing | Zendy; He Jianbo | Zendy; Deng Zhaoxiang | Zendy; Li Yulin | Zendy

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Base‐Sequence‐Independent Efficient Redox Switching of Self‐Assembled DNA Nanocages

Author(s) -

Wang Bang,

Song Lei,

Jin Bang,

Deng Ning,

Wu Xiaojing,

He Jianbo,

Deng Zhaoxiang,

Li Yulin

Publication year - 2019

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201900253

Subject(s) - nanocages , redox , dna , dna nanotechnology , nanotechnology , cysteamine , chemistry , cystamine , sequence (biology) , base pair , biophysics , combinatorial chemistry , materials science , biochemistry , biology , organic chemistry , catalysis

Stimuli responsivity has been extensively pursued in dynamic DNA nanotechnology, due to its incredible application potentials. Among diverse dynamic systems, redox‐responsive DNA assembly holds great promise for broad applications, especially considering that redox processes widely exist in various physiological environments. However, only a few studies have been reported on redox‐sensitive dynamic DNA assembly. Albeit ingenious, most of these studies are either dependent on the DNA sequence or involve chemical modification. Herein, a facile and universal mechanism to realize redox‐responsive self‐assembly of DNA nanocages (tetrahedron and cube) driven by the interconversion between cystamine and cysteamine toward dynamic DNA nanotechnology is reported.

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