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Lessons from a Minimal Genome: What Are the Essential Organizing Principles of a Cell Built from Scratch?
Author(s) -
Tarnopol Rebecca L.,
Bowden Sierra,
Hinkle Kevin,
Balakrishnan Krithika,
Nishii Akira,
Kaczmarek Caleb J.,
Pawloski Tara,
Vecchiarelli Anthony G.
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900249
Subject(s) - synthetic biology , component (thermodynamics) , genome , scratch , biology , living systems , nanotechnology , computational biology , cognitive science , computer science , genetics , ecology , psychology , gene , physics , materials science , operating system , thermodynamics
One of the primary challenges facing synthetic biology is reconstituting a living system from its component parts. A particularly difficult landmark is reconstituting a self‐organizing system that can undergo autonomous chromosome compaction, segregation, and cell division. Here, we discuss how the syn3.0 minimal genome can inform us of the core self‐organizing principles of a living cell and how these self‐organizing processes can be built from the bottom up. The review underscores the importance of fundamental biology in rebuilding life from its molecular constituents.