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Cell‐Penetrating Peptide Foldamers: Drug‐Delivery Tools
Author(s) -
Oba Makoto
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900204
Subject(s) - drug delivery , chemistry , cell penetrating peptide , peptidomimetic , peptide , amino acid , combinatorial chemistry , drug , nucleic acid , nanotechnology , biochemistry , organic chemistry , pharmacology , materials science , biology
Highly efficient drug‐delivery tools for membrane‐impermeable compounds, proteins, and nucleic acids in living cells are useful in the fields of chemical biology and drug discovery, and such tools have been widely studied. One strategy in the development of novel drug‐delivery tools is to utilize cell‐penetrating peptide (CPP) foldamers. CPP foldamers are folded oligopeptides that possess cell membrane permeability. In recent decades, a wide variety of CPP foldamers have been reported by many groups. Herein, CPP foldamers are introduced and discussed from the viewpoints of component monomers (amino acids) and their application as drug‐delivery tools.