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Direct Radiation Effects on the Structure and Stability of Collagen and Other Proteins
Author(s) -
Lalande Mathieu,
Schwob Lucas,
Vizcaino Violaine,
Chirot Fabien,
Dugourd Philippe,
Schlathölter Thomas,
Poully JeanChristophe
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900202
Subject(s) - radical , covalent bond , biophysics , chemistry , fragmentation (computing) , irradiation , protein stability , protein structure , nanotechnology , materials science , biochemistry , physics , biology , organic chemistry , ecology , nuclear physics
In this review, recent progress in understanding the direct effects of radiation on the structure and stability of collagen, the most abundant protein in the human body, and other proteins is surveyed. Special emphasis is placed on the triple‐helical structure of collagen, as studied by means of collagen mimetic peptides. The emerging patterns are the dose dependence of radiation processes and their abundance, the crucial role of radicals in covalent‐bond formation (crosslinking) or cleavage, and the influence of the radiation energy and nature. Future research should allow fundamental questions, such as charge transfer and fragmentation dynamics triggered by ionization, to be answered, as well as developing applications such as protein‐based biomaterials, notably with properties controlled by irradiation.