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Modular Enzyme‐ and Light‐Based Activation of Cyclopropene–Tetrazine Ligation
Author(s) -
Jiang Ting,
Kumar Pratik,
Huang Wei,
Kao WeiSiang,
Thompson Adrian O.,
Camarda Frank M.,
Laughlin Scott T.
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900137
Subject(s) - cyclopropene , bioorthogonal chemistry , tetrazine , chemistry , reactivity (psychology) , enzyme , combinatorial chemistry , stereochemistry , biochemistry , click chemistry , organic chemistry , pathology , medicine , alternative medicine
We describe a modular activation strategy for cyclopropene–tetrazine ligation. This activation strategy uses chemically diverse enzyme‐ or photolabile protecting groups as cyclopropene reactivity cages. The linkages between the caging groups and cyclopropene are through carbamates, thus permitting the application of diverse cages to allow bioorthogonal reactivity by administering enzymes or light.