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Cover Feature: Recognition of ASF1 by Using Hydrocarbon‐Constrained Peptides (ChemBioChem 7/2019)
Author(s) -
Bakail May,
RodriguezMarin Silvia,
Hegedüs Zsófia,
Perrin Marie E.,
Ochsenbein Françoise,
Wilson Andrew J.
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900132
Subject(s) - peptide , chemistry , cover (algebra) , proteolysis , computational biology , histone , protein function , feature (linguistics) , combinatorial chemistry , stereochemistry , biochemistry , biology , gene , enzyme , engineering , mechanical engineering , linguistics , philosophy
The cover feature picture shows how inhibition of the histone H3‐ASF1 (anti‐silencing function 1) protein–protein interaction (PPI) represents a potential approach for the treatment of numerous cancers. To pursue this goal, a hydrocarbon constraint was used to pre‐organize the histone H3 peptide in α‐helical conformation; despite conferring protection against proteolysis, this constrained peptide unexpectedly exhibited enthalpy–entropy compensation in comparison to the natural sequence, in its binding of ASF1. More information can be found in the communication by F. Ochsenbein, A. J. Wilson et al. on page 891 in Issue 7, 2019 (DOI: 10.1002/cbic.201800633).