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Front Cover: Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro[4.4]non‐8‐ene (ChemBioChem 6/2019)
Author(s) -
Fu Chengzhang,
Xie Feng,
Hoffmann Judith,
Wang Qiushui,
Bauer Armin,
Brönstrup Mark,
Mahmud Taifo,
Müller Rolf
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900106
Subject(s) - biosynthesis , polyketide , chemistry , cofactor , stereochemistry , moiety , flavin group , halogenation , oxidative phosphorylation , biochemistry , organic chemistry , enzyme
The front cover picture shows the biosynthesis illustration of armeniaspirols, which contain an unusual spiro[4.4]non‐8‐ene moiety. The lake can be seen as a precursor pool for the biosynthesis of bacterial secondary metabolites. The chloropyrrole‐polyketide intermediates, which are symbolized as the fish, are assembled by using various precursors such as proline, acetyl‐CoA, alkylmalonyl‐CoA, and chlorine ions. The formation of the armeniaspirol backbone is catalyzed by pyrrolyl‐2‐carboxyl‐S‐PCP biosynthesis proteins, halogenases, and polyketide synthases. The angler stands for Ams15, which forms the des‐ N ‐methyl spiro intermediates. The fishing rod represents the potential flavin cofactor used by Ams15, which has been shown to be essential for spiro formation through an oxidative dehalogenation process. More information can be found in the communication by R. Müller et al. on page 764 in Issue 6, 2019 (DOI: 10.1002/cbic.201800791).