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Cover Feature: INH14, a Small‐Molecule Urea Derivative, Inhibits the IKKα/β‐Dependent TLR Inflammatory Response (ChemBioChem 5/2019)
Author(s) -
Drexel Meinrad,
Kirchmair Johannes,
SantosSierra Sandra
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900081
Subject(s) - iκb kinase , cover (algebra) , chemistry , inflammatory response , regulator , inflammation , kinase , small molecule , feature (linguistics) , nf κb , microbiology and biotechnology , biochemistry , signal transduction , biology , immunology , philosophy , gene , mechanical engineering , linguistics , engineering
The cover feature picture shows INH14 ( N ‐(4‐ethylphenyl)‐ N′ ‐phenylurea), a small molecule that targets the kinases IKKα and IKKβ. INH14 reduces the activity of NF‐kB, a master regulator of inflammation. The activity of several pathways that coalesce at the level of IKKα/β (e.g., TLRs and TNF‐R) is diminished by treatment with INH14. More information can be found in the full paper by S. Santos‐Sierra et al. on page 710 in Issue 5, 2019 (DOI: 10.1002/cbic.201800647).