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Recent Developments in Metal‐Catalyzed Bio‐orthogonal Reactions for Biomolecule Tagging
Author(s) -
Jang SeYoung,
Murale Dhiraj P.,
Kim Anne Doyoung,
Lee JunSeok
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201900052
Subject(s) - biomolecule , chemistry , combinatorial chemistry , catalysis , nanotechnology , macromolecule , chemical biology , biocompatible material , organic chemistry , biochemistry , materials science , medicine , biomedical engineering
With the rapid advances in single‐molecule and live‐cell imaging studies to investigate biological problems, the role of chemical probes to monitor reactions in a live cell has considerably increased. However, selective labeling of a target protein or a specific residue is highly challenging due to the high complexity of the biological system. In particular, biological macromolecules (such as proteins, DNA, or RNA) share many functional groups that potentially cross‐react with exogenous chemical probes. Thus, there are high demands for perfect biocompatible reactions utilizing biologically unavailable chemistry. Metal‐catalyzed reactions have been extensively investigated as synthetic methodology studies, including initial attempts in applying the chemistry in aqueous solutions in vitro or even in biological conditions. Herein, the latest developments and progress in metal‐catalyzed bio‐orthogonal reactions for biomolecule labeling are summarized.