Premium
Cover Feature: Determination of Aqueous Two‐Phase System Binodals and Tie‐Lines by Electrowetting‐on‐Dielectric Droplet Manipulation (ChemBioChem 2/2019)
Author(s) -
Kojima Taisuke,
Lin ChuChi,
Takayama Shuichi,
Fan ShihKang
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800804
Subject(s) - electrowetting , ethylene glycol , phase (matter) , dielectric , materials science , chemical engineering , peg ratio , aqueous solution , nanotechnology , chemistry , chemical physics , analytical chemistry (journal) , chromatography , organic chemistry , optoelectronics , engineering , finance , economics
The cover feature picture shows biphasic droplets manipulated by electrowetting‐on‐dielectric (EWOD). We fabricated a “smart microscope slide” where aqueous droplets containing dextran (DEX) and poly(ethylene glycol) (PEG) macromolecules were prepared, mixed, and agitated by EWOD. In the droplets, liquid–liquid phase dynamics emerge depending on a DEX–PEG concentration, showing homogeneous, locally phase‐separated, or globally phase‐separated states. Facile observation of the droplets allows quantification of phase diagrams and sheds light on macromolecular crowding effects on liquid–liquid phase separation. More information can be found in the full paper by S. Takayama, S.‐K. Fan et al. on page 270 in Issue 2, 2019 (DOI: 10.1002/cbic.201800553).