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Front Cover: Photoactivatable Myristic Acid Probes for UNC119‐Cargo Interactions (ChemBioChem 2/2019)
Author(s) -
Kaiser Nadine,
Mejuch Tom,
Fedoryshchak Roman,
Janning Petra,
Tate Edward W.,
Waldmann Herbert
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800803
Subject(s) - myristic acid , myristoylation , diazirine , chemistry , covalent bond , front cover , biophysics , biochemistry , stereochemistry , membrane , cover (algebra) , biology , organic chemistry , fatty acid , mechanical engineering , palmitic acid , engineering
The front cover picture shows , in the top left‐hand corner, a photoactivatable myristic acid analogue, termed Pacman (green), in complex with the lipoprotein‐binding UNC119 protein (red), which facilitates the trafficking of myristoylated proteins between cellular membranes. Upon irradiation, the diazirine‐containing Pacman probe covalently binds to UNC119 in complex protein mixtures. Pacman is a substrate for several N‐myristoyl transferases of protozoan parasites and could be a valuable tool for investigating protein–protein and protein–lipid interactions involving myristoylated proteins. More information can be found in the communication by H. Waldmann et al. on page 134 in Issue 2, 2019 (DOI: 10.1002/cbic.201800406).