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Front Cover: Alkyne‐Tagged Analogue of Jaspine B: New Tool for Identifying Jaspine B Mode of Action (ChemBioChem 23/2018)
Author(s) -
Rozié Alexandrine,
Santos Cécile,
Fabing Isabelle,
Calsou Patrick,
Britton Sébastien,
Génisson Yves,
Ballereau Stéphanie
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800689
Subject(s) - click chemistry , mode of action , alkyne , cover (algebra) , front cover , chemistry , stereochemistry , bioorthogonal chemistry , enantiomer , fluorophore , combinatorial chemistry , nanotechnology , biochemistry , physics , materials science , optics , fluorescence , engineering , mechanical engineering , catalysis
The front cover picture shows how, thanks to new Jaspine B‐derived cellular probes, click chemistry illuminates the yet unknown cytotoxic mode of action of this potential anticancer agent. Inspired by the natural compound extracted from the marine sponge Jaspis sp. (left corner), clickable analogues were designed and synthesized in order to achieve in cellulo labeling through a click chemistry reaction with an appropriate fluorophore. These experiments revealed that the most active enantiomer of Jaspine B specifically accumulates in the cytoplasm of human cells in large aggregates, as shown in the cellular images in the background. More information can be found in the communication by S. Britton, S. Ballereau, et al. on page 2438 in Issue 23, 2018 (DOI: 10.1002/cbic.201800496). Sponge image ©IRD/Georges Bargibant, used with permission.