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Cover Feature: A Photoenzymatic NADH Regeneration System (ChemBioChem 22/2018)
Author(s) -
Höfler Georg T.,
FernándezFueyo Elena,
Pesic Milja,
Younes Sabry H.,
Choi EunGyu,
Kim Yong H.,
Urlacher Vlada B.,
Arends Isabel W. C. E.,
Hollmann Frank
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800654
Subject(s) - nad+ kinase , cover (algebra) , chemistry , regeneration (biology) , electron transfer , stereoselectivity , enzyme , redox , reductase , biochemistry , stereochemistry , combinatorial chemistry , biology , photochemistry , catalysis , organic chemistry , microbiology and biotechnology , mechanical engineering , engineering
The cover feature picture shows the concept of photoenzymatic regeneration of NADH from its oxidised form (NAD + ) by combining deazaflavin photocatalysts with a putidadoxin reductase (PDR). The photoexcited deazaflavin mediates electron transfer from a sacrificial electron donor to the NADH regeneration enzyme (PDR). The latter then selectively reduces NAD + to 1,4‐NADH, which in turn can be used, for example, for the stereoselective reduction of carbonyl groups into alcohols. More information can be found in the full paper by F. Hollmann et al. on page 2344 in Issue 22, 2018 (DOI: 10.1002/cbic.201800530).