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Front Cover: 2′‐ O ,4′‐ C ‐Methylene‐Bridged Nucleic Acids Stabilize Metal‐Mediated Base Pairing in a DNA Duplex (ChemBioChem 22/2018)
Author(s) -
Nakagawa Osamu,
Fujii Akane,
Kishimoto Yuki,
Nakatsuji Yusuke,
Nozaki Natsumi,
Obika Satoshi
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800653
Subject(s) - nucleic acid , locked nucleic acid , dna , base pair , duplex (building) , cytosine , chemistry , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , stereochemistry , biochemistry , oligonucleotide
The front cover picture shows that a 2′‐ O ,4′‐ C ‐methylene‐bridged nucleic acid (2′,4′‐BNA) or locked nucleic acid (LNA) forms a stable metal‐mediated base pair (MMBP) with an Ag I ion in a DNA/DNA duplex. 2′,4′‐BNA/LNA, which has a strictly fixed N‐type sugar conformation (C3′‐ endo ), can significantly stabilize duplexes with Watson–Crick base pairs. 2′,4′‐BNA/LNA is widely used to improve gene knockdown in nucleic acid‐based therapies. In our study, the effects of sugar conformation on MMBPs were investigated with 2′,4′‐BNA/LNA. 2′,4′‐BNA/LNA sugar significantly improved the duplex‐forming ability of the DNA/DNA complex containing a cytosine(C)‐Ag I ‐C MMBP compared to that of the unmodified sugar. The results indicate that 2′,4′‐BNA/LNA can be applied not only to nucleic acid‐based therapies but also to MMBP technologies. More information can be found in the full paper by O. Nakagawa, S. Obika, et al. on page 2372 in Issue 22, 2018 (DOI: 10.1002/cbic.201800448).