Colloidal Fluorophore Aggregates for the Selective Detection of Albumins in Solution and on Electrophoresis Gels | Zendy

Park Jihee | Zendy; Kim Youngmi | Zendy

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Colloidal Fluorophore Aggregates for the Selective Detection of Albumins in Solution and on Electrophoresis Gels

Author(s) -

Park Jihee,

Kim Youngmi

Publication year - 2019

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201800608

Subject(s) - fluorophore , human serum albumin , fluorescence , chemistry , reagent , chromatography , electrophoresis , serum albumin , human blood , albumin , biochemistry , biology , organic chemistry , physiology , physics , quantum mechanics

We report a fluorescent probe that is highly sensitive and selective for serum albumins. Signal transduction results from the disassembly of fluorescence‐quenched aggregates upon binding to human serum albumin (HSA). The probe offers a rapid (≤2 s) fluorometric assay of HSA in phosphate‐buffered saline, urine, or blood serum with a high signal‐to‐noise ratio. It is also useful as a wash‐free prestaining reagent for detecting HSA on electrophoresis gels.

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