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Improved Efficacy of Antibody Cancer Immunotherapeutics through Local and Sustained Delivery
Author(s) -
Huynh Vincent,
Jesmer Alexander H.,
Shoaib Muhammad M.,
D'Angelo Anthony D.,
Rullo Anthony F.,
Wylie Ryan G.
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800579
Subject(s) - antibody , immunotherapy , immune system , cancer , cancer research , medicine , immunology
Antibodies are a growing class of cancer immunotherapeutics that facilitate immune‐cell‐mediated killing of tumors. However, the efficacy and safety of immunotherapeutics are limited by transport barriers and poor tumor uptake, which lead to high systemic concentrations and potentially fatal side effects. To increase tumor antibody immunotherapeutic concentrations while decreasing systemic concentrations, local delivery vehicles for sustained antibody release are being developed. The focus of this review is to define the material properties required for implantable controlled antibody delivery and highlight the controlled‐release strategies that are applicable to antibody immunotherapeutics.