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Recent Advances in Artificially Sulfated Polysaccharides for Applications in Cell Growth and Differentiation, Drug Delivery, and Tissue Engineering
Author(s) -
Zeng Kui,
Groth Thomas,
Zhang Kai
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800569
Subject(s) - sulfation , polysaccharide , drug delivery , heparan sulfate , tissue engineering , chitosan , chemistry , heparin , biochemistry , drug , nanotechnology , biology , materials science , pharmacology , organic chemistry , genetics
Artificially sulfated polysaccharides, as the mimetics of native heparin and heparan sulfate, are important bioactive compounds, since they show great potential for tuning crucial biological activities within living organisms. Herein, we summarize progress in the development of artificially sulfated polysaccharides, such as cellulose sulfate, chitosan sulfate, and other sulfated polysaccharides, with a particular focus on the fields of biomedical and bioengineering applications in the past ten years. Their effects on cell growth and differentiation, but also as building blocks for drug carriers and medical implants, are emphasized.