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Cover Feature: Direct Access to Medium‐Chain α,ω‐Dicarboxylic Acids by Using a Baeyer–Villiger Monooxygenase of Abnormal Regioselectivity (ChemBioChem 19/2018)
Author(s) -
Yu JiaMei,
Liu YuanYang,
Zheng YuCong,
Li Hao,
Zhang XiaoYan,
Zheng GaoWei,
Li ChunXiu,
Bai YunPeng,
Xu JianHe
Publication year - 2018
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800546
Subject(s) - regioselectivity , chemistry , hydrolysis , monooxygenase , organic chemistry , dicarboxylic acid , stereochemistry , enzyme , catalysis , cytochrome p450
The cover feature picture shows a novel Baeyer–Villiger monooxygenase of high abnormal regioselectivity, which was discovered from Pseudomonas aeruginosa ( Pa BVMO). Pa BVMO was used to transform plant‐oil‐based keto fatty acids into medium‐chain α,ω‐dicarboxylic acids through a Baeyer–Villiger oxidation–hydryolysis cascade. Pa BVMO displayed the highest abnormal regioselectivity toward a variety of long‐chain (C 16 –C 20 ) aliphatic keto acids to date, affording dicarboxylic monoesters with a ratio of up to 95 %. Upon chemical hydrolysis, α,ω‐dicarboxylic acids and fatty alcohols are readily obtained without further treatment; this dramatically reduces the synthetic steps of α,ω‐dicarboxylic acids from renewable oils and fats. More information can be found in the communication by Y.‐P. Bai, J.‐H. Xu, et al. on page 2049 in Issue 19, 2018 (DOI: 10.1002/cbic.201800318).