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Fluorescence Imaging of Alzheimer's Disease with a Flat Ensemble Formed between a Quinoline–Malononitrile AIEgen and Thin‐Layer Molybdenum Disulfide
Author(s) -
Dou WeiTao,
Zhang JingJing,
Li Qiang,
Guo Zhiqian,
Zhu Weihong,
Chen GuoRong,
Zhang HaiYan,
He XiaoPeng
Publication year - 2019
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201800508
Subject(s) - molybdenum disulfide , quinoline , fluorescence , malononitrile , chemistry , molybdenum , layer (electronics) , combinatorial chemistry , aqueous solution , biophysics , nanotechnology , materials science , biochemistry , organic chemistry , biology , physics , quantum mechanics , metallurgy , catalysis
The sensitive imaging of amyloid‐β (Aβ) peptides is important for the timely detection of neurodegenerative diseases, such as Alzheimer's disease (AD). Although clinically the diagnosis of AD relies on the use of radiolabeled imaging reagents, herein we report the simple construction of a “flat ensemble” formed between a quinoline–malononitrile AIEgen (EDS) and thin‐layer molybdenum disulfide (2D MoS 2 ) for the sensitive detection of Aβ by means of fluorescence‐based techniques. Self‐assembly between EDS and 2D MoS 2 in aqueous buffer solution produces the flat ensemble, and the subsequent interaction of the material ensemble with oligomeric and aggregated Aβ peptides leads to up to 19‐fold enhanced fluorescence of EDS. The ensemble is also applicable for staining Aβ aggregates in vivo.